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journal of experimental & clinical cancer research | home page skip to content advertisement menu explore journals get published about bmc login my account search search all bmc articles search journal of experimental & clinical cancer research menu home about articles submission guidelines search submit a manuscript celebrating the 10th anniversary partnership with bmc ​​​​​​​2018 marks the 10 th anniversary of the partnership between the journal of experimental & clinical cancer research and bmc. over the past decade, the journal has established itself among some of the top oncology titles in journal citation reports. click here to look back at some of the journal’s milestone achievements and best content from the past 10 years. featured article: integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma integrins mediate cell-cell and cell-extracellular matrix interactions. particularly, integrins αvβ3, αvβ5 and α5β1 mediate tumor angiogenesis and metastasis, and have become promising targets for the treatment of advanced cancer. r. huang and e. k. rofstad review the integrin isoforms responsible for angiogenesis and organ-specific metastasis in malignant melanoma and the inhibitors that have been considered for the future treatment of metastatic disease. click here to access the full article. click here to access all of the reviews published to date in journal of experimental & clinical cancer research . aims and scope journal of experimental & clinical cancer research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology. please click here to read more. articles recent most accessed content type: research | 12 october 2018 andrographolide inhibits breast cancer through suppressing cox-2 expression and angiogenesis via inactivation of p300 signaling and vegf pathway authors: yulin peng, yan wang, ning tang, dongdong sun, yulong lan, zhenlong yu, xinyu zhao, lei feng, baojing zhang, lingling jin, fabiao yu, xiaochi ma and chuanzhu lv content type: research | 11 october 2018 mechanism of pir-dq590027/mir17hg regulating the permeability of glioma conditioned normal bbb authors: xue leng, jun ma, yunhui liu, shuyuan shen, hai yu, jian zheng, xiaobai liu, libo liu, jiajia chen, lini zhao, xuelei ruan and yixue xue content type: research | 11 october 2018 gli2 promotes cell proliferation and migration through transcriptional activation of arhgef16 in human glioma cells authors: dengliang huang, yiting wang, linlin xu, limin chen, minzhang cheng, wei shi, huanting xiong, detina zalli and shiwen luo content type: research | 5 october 2018 acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules authors: zaira boussadia, jessica lamberti, fabrizio mattei, elisabetta pizzi, rossella puglisi, cristiana zanetti, luca pasquini, federica fratini, luca fantozzi, federica felicetti, katia fecchi, carla raggi, massimo sanchez, stefania d’atri, alessandra carè, massimo sargiacomo… content type: research | 4 october 2018 inhibition of stat3 blocks protein synthesis and tumor metastasis in osteosarcoma cells authors: dongqing zuo, kristen l shogren, jie zang, donna e jewison, brian e waletzki, alan l miller ii, scott h okuno, zhengdong cai, michael j yaszemski and avudaiappan maran most recent articles rss view all articles content type: review | 26 september 2011 apoptosis in cancer: from pathogenesis to treatment authors: rebecca sy wong content type: review | 6 october 2015 metabolic reprogramming: the emerging concept and associated therapeutic strategies authors: go j. yoshida content type: research | 3 february 2016 hif-2α promotes epithelial-mesenchymal transition through regulating twist2 binding to the promoter of e-cadherin in pancreatic cancer authors: jian yang, xu zhang, yi zhang, dongming zhu, lifeng zhang, ye li, yanbo zhu, dechun li and jian zhou content type: research | 14 september 2009 characterization of human breast cancer epithelial cells (hbcec) derived from long term cultured biopsies authors: ralf hass and catharina bertram content type: research article | 5 february 2015 elevated kinesin family member 26b is a prognostic biomarker and a potential therapeutic target for colorectal cancer authors: jingtao wang, feifei cui, xiao wang, yingming xue, jian chen, yang yu, huijun lu, meng zhang, huamei tang and zhihai peng most accessed articles rss view all articles meeting reports now accepted journal of experimental & clinical cancer research now welcomes the submission of meeting reports to help showcase novel developments presented at meetings and conferences. please click here for more information on the article types accepted by journal of experimental & clinical cancer research . editor-in-chief mauro castelli, regina elena national cancer institute, italy if you would like to contact journal of experimental & clinical cancer research, please send an email to: [email protected]​​​​​​​ 2017 impact factor we are delighted to share with our readers that journal of experimental & clinical cancer research has an impact factor of 6.217 and is currently ranked at 33 out of 222 (q1) in the oncology category of journal citation reports (clarivate analytics, 2018). we would like to extend our appreciation to all editorial board members, authors and peer reviewers who have contributed to the journal and enabled this achievement. archival content journal of experimental & clinical cancer research has been publishing since 1982. prior to publishing with biomed central from 2008, journal of experimental & clinical cancer research was published in print. for enquiries about previous content, please contact us on: [email protected] reviewer acknowledgement the editorial team of journal of experimental & clinical cancer research would like to thank all of our reviewers who have contributed to the journal. click here to visit the reviewer acknowledgements page. advertisement owned by the association for international promotion & study in tumors (apsit) official journal of the regina elena national cancer institute , italy editorial board sign up for article alerts and news from this journal submit a manuscript follow follow us on twitter 2017 journal metrics speed 30 days from submission to first decision 89 days from submission to acceptance 14 days from acceptance to publication citation impact 6.217 - 2-year impact factor 5.280 - 5-year impact factor 1.350 - source normalized impact per paper (snip) 2.000 - scimago journal rank (sjr) usage 599,727 downloads 364 altmetric mentions more about our metrics advertisement journal of experimental & clinical cancer research issn: 1756-9966 contact us submission enquiries: access here and click contact us general enquiries: [email protected] explore journals get published about bmc read more on 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